Professor Mohiuddin
(a graduate of Dow Medical College Karachi), director of xenotransplantation, University of Maryland School of Medicine, was a member of team of Scientists Perform Historic First Successful Transplant of a pig Heart into Adult Human with End-Stage Heart Disease. ( It Was Patient’s Only Option for Survival after Being Deemed Ineligible for Traditional Transplant January 10, 2022
BALTIMORE – In a first-of-its-kind surgery, a 57-year-old patient with terminal heart disease received a successful transplant of a genetically-modified pig heart and is still doing well three days later. It was the only currently available option for the patient. The historic surgery was conducted by University of Maryland School of Medicine (UMSOM) faculty at the University of Maryland Medical Center (UMMC),
This organ transplant demonstrated for the first time that a genetically-modified animal heart can function like a human heart without immediate rejection by the body. “This was a breakthrough surgery and brings us one step closer to solving the organ shortage crisis. There are simply not enough donor human hearts available to meet the long list of potential recipients,” said Bartley P. Griffith, MD, who surgically transplanted the pig heart into the patient.
Considered one of the world’s foremost experts on transplanting animal organs, known as xenotransplantation, Muhammad M. Mohiuddin, MD, Professor of Surgery at UMSOM, joined the UMSOM faculty five years ago and established the Cardiac Xenotransplantation Program with Dr. Griffith. Dr. Mohiuddin serves as the program’s Scientific/Program Director and Dr. Griffith as its Clinical Director.
About 110,000 Americans are currently waiting for an organ transplant, and more than 6,000 patients die each year before getting one, according to the federal government’s organdonor.gov. Xenotransplantation could potentially save thousands of lives but does carry a unique set of risks, including the possibility of triggering a dangerous immune response. These responses can trigger an immediate rejection of the organ with a potentially deadly outcome to the patient.
Revivicor, a regenerative medicine company based in Blacksburg, VA, provided the genetically-modified pig to the xenotransplantation laboratory at UMSOM. On the morning of the transplant surgery, the surgical team, led by Dr. Griffith and Dr. Mohiuddin, removed the pig’s heart and placed it in the XVIVO Heart Box, perfusion device, a machine that keeps the heart preserved until surgery.
The pig had 10 genetic modifications. Four genes were knocked out, or inactivated, including one that encodes a molecule that causes an aggressive human rejection response. Six human genes responsible for immune acceptance of the pig heart were inserted into the genome. A growth gene was also inactivated to prevent the pig’s heart from continuing to grow after it was implanted, said Dr. Mohiuddin,who, with Dr. Griffith, did much of the research leading up to the transplant.
The breakthrough may lead one day to new supplies of animal organs for transplant into human patients.
But there is an acute shortage of organs, and about a dozen people on the lists die each day. Some 3,817 Americans received human donor hearts last year as replacements, more than ever before, but the potential demand is still higher.
Professor Muhammad M. Mohiuddin,Graduated , Dow Medical College, Karachi, Pakistan 1989, 1991-1993 Fellowship, Transplantation Biology and Immunology University of Pennsylvania Medical Center 1993-1998 Fellowship, Transplantation Surgery, Department of Cardiothoracic Surgery, MCP-Hahnemann Medical School 1997-1998 Fellowship, Bone marrow Transplantation, Institute for Cellular Therapeutics, Allegheny University of the Health Sciences, Philadelphia, Dr. Mohiuddin recently served as chief of transplantation section of Cardiothoracic Surgery Research Program and Senior Scientist at the National Heart Lung and Blood Institute of the National Institutes of Health. Before joining NIH in 2005 he held faculty positions at University of Pennsylvania, Philadelphia and Rush University, Chicago. Dr. Mohiuddin is involved in the field of xenotransplantation since 1992 and has been instrumental in starting the xenotransplantation research programs at the above institutions. He has received several NIH and non-NIH grants during his academic career. His recent work in cardiac xenotransplantation was highlighted widely in press throughout the world.
https://www.nytimes.com/2022/01/10/health/heart-transplant-pig-bennett.html
https://www.newswise.com/articles/university-of-maryland-school-of-medicine-faculty-scientists-and-clinicians-perform-historic-first-successful-transplant-of-porcine-heart-into-adult-human-with-end-stage-heart-disease
Imperial College London names library after Pakistani scientist Prof. Abdus Salam
By Web Desk | Sunday, Jul 02, 2023
The United Kingdom's Imperial College London has announced to name its Central Library after Professor Abdus Salam, the Pakistani Nobel laureate and physicist to honour his legacy and inspire future generations.
The development came after the university's board made the decision as part of their ongoing response to a report by the History Group, which brought into the spotlight under-celebrated individuals and historical figures who've been associated with the university.
University's President Hugh Brady expressed his admiration for Professor Salam's significant contributions to the educational institution and the field of physics.
"Throughout his career, the Nobel Prize winning Professor of Theoretical Physics Abdus Salam made a tremendous contribution to Imperial, as well as to the world of physics and science more generally. It is right that we do more to celebrate this legacy. I hope the new Abdus Salam Library inspires many more people in the years to come," he said.
The report recognises the contribution of academics like Professor Salam through their ongoing work to recognise them, which includes initiatives such as physical commemorations on campuses, portraiture and scholarships.
In 1957, the Pakistani physicist joined the prestigious educational institution and played a pivotal role in setting up the Theoretical Physics Department alongside the late Professor Paul T Matthews. His groundbreaking work on the electroweak unification theory led to him sharing the Nobel Prize in 1979.
Beyond his scientific accomplishments, the Pakistani scientist was a staunch advocate for science education in developing countries. He also founded the International Centre for Theoretical Physics in 1964, which offered scientists from developing countries with opportunities to work with leading field experts.
The library's formal launch and naming ceremony has been planned for the upcoming academic year, where the university community will gather to celebrate his remarkable contributions to science and education.
Professor Abdus Salam and Professor Oppenheimer at Princeton University in 1960
Pakistan’s Nobel Prize-winning physicist Dr. Abdus Salam, met Dr. Oppenheimer at the University of Princeton. Salam and Oppenheimer became friends and would engage in meetings, delving into the theories of Mathematics and Physics. In 1960, Salam established a research group of theoretical physics followed by proposing the idea of an Intl. Center for Theoretical Physics, in 1964, the ICTP was founded in Italy, with Salam as its director.
Soborno Isaac Bari
Soborno Issac Bari, who’s the youngest professor the world over, and those who regularly knew him as a present-day time Einstein.
He is an 11-Year old professor who’s a Muslim Bengali-American prodigy.
Unlike different children, Soborno Isaac Bari had left his dad and mom, and the arena in shock. At the age of two, while a normal infant ought to slightly talk about this phenomenon, toddlers became celebrated during the arena for fixing Ph.D.
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